Name | WD2000-012547 |
Synonyms | 283172-68-9 WD2000-012547 6H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one, 1,3,4,5-tetrahydro-2-phenyl- |
CAS | 283172-68-9 |
Molecular Formula | C17H14N2O |
Molar Mass | 262.30586 |
Density | 1.270±0.06 g/cm3(Predicted) |
Melting Point | 249-255 °C (decomp) |
Boling Point | 600.2±44.0 °C(Predicted) |
pKa | 14.94±0.20(Predicted) |
Storage Condition | 2-8℃ |
Use | WD2000-012547 was a selective PARP-1 inhibitor with a pKi of 8.221. |
In vitro study | Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. WD2000-012547 (Compound 66) is a representative PARP-1 inhibitor with a pK i of 8.221. |